Post-doctoral position in the modulation of GPCR phramacology with nanobodies Physiology of Reproduction and Behaviours Unit, Nouzilly, France.
The project in which the post-doctoral fellow will be involved is based on the discovery, characterization and optimization of nanobodies capable of selectively modulating the activity of GPCRs controlling follicular development, steroidogenesis and ovulation.
Qualifications: The post-doctoral fellow will have to perform: i) pharmacological profiling and trafficking measurements using HTRF and BRET methods; ii) phage-display; iii) production, purification and characterization of recombinant proteins; iv) kinetic-rate constants determination; v) flow cytometry; vi) ELISA/HTRF assays; vi) histology/immunohistochemistry. The successful candidate will have prior experience in several of these approaches. He/she must have worked and/or have solid knowledge in biochemistry, cell biology, molecular pharmacology. Experience/knowledge in reproductive biology, antibody development/engineering, GPCR pharmacology and/or in vivo testing/phenotyping will also be appreciated. We seek for a highly motivated candidate capable of working both independently and as part of a team; endowed of excellent problem solving, organizational and communication skills. Prior international experience will be considered as an asset.
Lab website: http://bios.tours.inra.fr/
Junior R&D Project Leader in Biochemistry at CALIXAR (CDI - CALIXAR- Lyon, France)
You will participate in the development and the successful realization of R&D challenging projects for different clients, pharmaceutical and biotech companies (USA, Europe, Japan, ...). In contact with these clients and under the supervision of your project leader, you will propose and implement co-development programs in line with their specifications all the way through to the completion of the projects. With driving force, you will be involved in implementing the best state of the art in the field, researching and developing the new protocols. You will carry out the implementation of the different techniques (expression, extraction, purification, stabilization, characterization) for the generation and study of complex targets (especially membrane proteins) in the laboratory and/or with the help of partners. You will report on project results and follow-up to your clients and could be involved in drafting patents and publications. Finally, you will ensure a regular scientific watch allowing you to establish the technical expertise of the company.
The candidate will be in full autonomy as soon as possible on client projects.
A permanent INRAE researcher position in artificial intelligence, statistics and cell signaling networks is open for 2021 external competitions in the BIOS (Biologie des Systèmes de Signalisation) team within the PRC (Physiologie de la Reproduction et des Comportements) unit in Nouzilly near Tours (37).
See the research profil on INRAE Jobs site: https://jobs.inrae.fr/en/open-competitions/open-competions-research-scientists-job-profiles-crcn/cr-2021-phase-2
Application deadline: March 04, 2021.
POSTDOCTORAL POSITION IN GPCR PHARMACOLOGY
Institut des Biomolécules Max Mousseron (IBMM), Montpellier
Working environment: A 18 months postdoctoral position is available starting on March 1st 2021 in the “Cell Pharmacology” group of the Institut des Biomolécules Max Mousseron (IBMM –UMR CNRS 5247). The IBMM is a multidisciplinary research center that provides a stimulating and collaborative working environment for scientists conducting research on the design, the synthesis and the pharmacology of potential future drugs.Our group is interested in how the signal is transmitted via a particular class of membrane receptors, G protein-coupled receptors (GPCRs). The project in which the post-doctoral fellow will be involved is based on the characterization of the complex formed by the ghrelin and dopamine receptors; this heteromer is directly involved in the control of food intake.
Main mission: The post-doctoral fellow will be in charge of the characterization of bivalent compounds targeting the dimer formed by the ghrelin and dopamine receptors using model systems of increasing complexity (purified receptors, cell lines, animal models), to both validate this complex as a possible target for treating food-intake disorders and illuminate the impact of receptor dimerization on ghrelin-mediated signaling.
Activities: The post-doctoral fellow will have to delineate the pharmacological profiles of the ligands-binding affinity, activation of G proteins, production of second messengers, recruitment of arrestin using the receptors purified in lipid nanodiscs as well as cell lines expressing the different combinations of receptors. As part of his/her activity, he/she will have to design the experimental plan, implement the corresponding studies, analyze the results, put them back in the context of the literature and communicate them through oral and written presentations.
Qualifications: The post-doctoral fellow will have to perform ligandbinding and signaling protein activation experiments using fluorescence and bioluminescence transfer methods, essentially. The candidate will thus need to have an experience in a related topic. He/she must have worked and/or have solid knowledge in biochemistry (protein handling), cell biology (cell culture, transfection), pharmacology (binding assays, production of second messengers, etc.) as well as basic knowledge of medicinal chemistry concepts. Experience and/or knowledge in fluorescence and bioluminescence transfer methods (HTRF, BRET, FRET) will also be appreciated, as will expertise in GPCR pharmacology. The candidate is expected to be able to work both independently and as part of a team and he/she will have with excellent problem-solving, organizational and communication skills.
Lab website:https://www.ibmmpharmaco.com/More information on salary and conditions at: https://euraxess.ec.europa.eu/jobs/584097
The Faculty of Science and Leiden Academic Centre for Drug Research are looking for a
Tenure Track position in Medicinal Chemistry
We offer an attractive research and teaching environment, including scientific independence, a collaborative atmosphere, attractive start-up packages and a personal career-development track, including mentoring and support.
The candidate will establish and maintain an independent internationally recognized research program in medicinal chemistry within the division of Drug Discovery and Safety. The candidate will contribute to the teaching tasks, and share other responsibilities of the division and the Leiden Academic Centre for Drug Research (LACDR). Candidates from the (broad) field of medicinal chemistry are invited to apply. Candidates aspire to excel in their discipline, and are open to collaborate within the institute with complementary disciplines, as well as those within our faculty. Candidates are expected to contribute to the teaching programs of LACDR, which include Bachelor and Master programs in Biopharmaceutical Sciences (BPS), as well as the Master program in Pharmacy. The position has a variety of tasks depending on the entry level as an assistant professor or associate professor:
Our Tenure track is expected to lead to a tenured position as associate professor and grow into the role of a full professor. With our Tenure track we offer you a clear and inviting career path to support you in the development of your personal and professional talents. It has a strong focus on coaching and training. A special mentor program is offered with fellow Tenure Trackers in a peer group, in order to develop your academic leadership skills. You can read more about our Tenure Track:
The Faculty of Science at Leiden University is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelors’ and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2,200 staff and over 4,200 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.
The Leiden Academic Centre for Drug Research (LACDR) is a leading institute dedicated to world-class research and education in drug discovery and development. LACDR comprises a diverse and international team of approximately 150 researchers. The research conducted at the LACDR is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine & Pharmacology. The various research topics carried out within these themes are ideal for executing interdisciplinary research from, a strong monodisciplinary basis.
Terms and conditions
The track consists of a temporary appointment for a period of six years maximum. The gross monthly salary at assistant professor level is between € 3.746,- and € 5.826,- depending on your level of experience. (pay scale 11 or 12 in accordance with the Collective Labour Agreement for Dutch Universities).
An appointment with Leiden University includes a pension build-up and other benefits; these include an annual holiday premium of 8%, an end-of-year premium of 8.3% and a paid parental leave of 62,5%. Candidates from outside the Netherlands may be eligible for a substantial tax break.
Dual Career Programme
Leiden University offers a Dual Career Programme (DCP) to assist the life partners of new academic staff (on pay-roll) in finding employment in The Netherlands. The programme is offered in close cooperation with nearby universities of Delft and Rotterdam (Erasmus). Candidates from outside the Netherlands may be eligible for a substantial tax break
University Teaching Qualification (UTQ). For more information on the UTQ please go to our teacher qualification page on our website. Newly appointed staff is expected to obtain this qualification within 2-3 years from their appointment.
At the Faculty of Science we value inclusiveness and strive for a diverse community with equal opportunities for all. We give full support to our staff in achieving their potential to become independent academic researchers and teachers. For more information about our policy on diversity and equality please go to the diversity page on our website. Hence, Leiden University especially welcomes applications from members of underrepresented groups.